DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease

Table 1

Demographic and neuropsychological features of CTRL, MCI, and AD patients.

					Student’s t-test
Characteristics	CTRL (𝑁=18)	MCI (𝑁=10)	AD (𝑁=10)	* 𝑃 value	CTRL versus MCI	CTRL versus AD	MCI versus AD
Gender female (n, %)	13, 0.72	5, 0.50	8, 0.80	.325	—	—	—
Age (years)	69.1±5.5	70.8±5.9	72.1±4.8	.273	—	—	—
Verbal memory	11.5±2.2	7.3±3.9	4.7±3.2	<.001	0.001	<0.001	n.s.
MMSE	28.8±1.1	25.5±2.3	22.1±2.7	<.001	<0.001	<0.001	0.007

* Statistical analysis: Kruskal-Wallis nonparametric comparison; 𝑃<.05 is considered significant.
Values are expressed in mean ± SD. CTRL: healthy controls; MCI: mild cognitive impairment; AD: Alzheimer’s disease; MMSE: mini-mental state examination.