Research Article

DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease

Table 3

Mean Diffusivity (×10−3 mm2 s−1) in CTRL, MCI, and AD patients.

CTRL ( )MCI ( )AD ( )Student t-test*
Mean(SD)Mean(SD)Mean(SD)CTRL versus MCICTRL versus ADMCI versus AD

Brain tissue0.949(0.038)0.967(0.031)0.996(0.026)n.s.0.0020.035
White matter0.809(0.030)0.825(0.023)0.833(0.018)n.s.0.025n.s.
Grey matter0.979(0.042)1.006(0.037)1.053(0.036)n.s.<0.0010.011
Left PC/PCC1.071(0.045)1.097(0.110)1.170(0.078)n.s.<0.001n.s.
Right PC/PCC1.036(0.045)1.077(0.086)1.128(0.096)n.s.0.002n.s.
Left hippocampus1.051(0.071)1.147(0.078)1.242(0.117)0.003<0.0010.047
Right hippocampus1.097(0.083)1.191(0.110)1.275(0.120)0.016<0.001n.s.
Left hipp-PC/PCC0.965(0.065)1.036(0.104)1.107(0.070)0.034<0.001n.s.
Right hipp-PC/PCC0.972(0.064)1.052(0.091)1.081(0.024)0.011<0.001n.s.

* Statistical analysis: Student t-test for independent sample; is considered significant.
Values are expressed in mean (SD). CTRL: healthy controls; MCI: mild cognitive impairment; AD: Alzheimer’s disease; n.s.: not significant; Hipp-PC/PCC: hippocampus to PC/PCC tract.