DTI and MR Volumetry of Hippocampus-PC/PCC Circuit: In Search of Early Micro- and Macrostructural Signs of Alzheimers's Disease
Table 3
Mean Diffusivity (×10−3 mm2 s−1) in CTRL, MCI, and AD patients.
CTRL ()
MCI ()
AD ()
Student t-test*
Mean
(SD)
Mean
(SD)
Mean
(SD)
CTRL versus MCI
CTRL versus AD
MCI versus AD
Brain tissue
0.949
(0.038)
0.967
(0.031)
0.996
(0.026)
n.s.
0.002
0.035
White matter
0.809
(0.030)
0.825
(0.023)
0.833
(0.018)
n.s.
0.025
n.s.
Grey matter
0.979
(0.042)
1.006
(0.037)
1.053
(0.036)
n.s.
<0.001
0.011
Left PC/PCC
1.071
(0.045)
1.097
(0.110)
1.170
(0.078)
n.s.
<0.001
n.s.
Right PC/PCC
1.036
(0.045)
1.077
(0.086)
1.128
(0.096)
n.s.
0.002
n.s.
Left hippocampus
1.051
(0.071)
1.147
(0.078)
1.242
(0.117)
0.003
<0.001
0.047
Right hippocampus
1.097
(0.083)
1.191
(0.110)
1.275
(0.120)
0.016
<0.001
n.s.
Left hipp-PC/PCC
0.965
(0.065)
1.036
(0.104)
1.107
(0.070)
0.034
<0.001
n.s.
Right hipp-PC/PCC
0.972
(0.064)
1.052
(0.091)
1.081
(0.024)
0.011
<0.001
n.s.
* Statistical analysis: Student t-test for independent sample; is considered significant. Values are expressed in mean (SD). CTRL: healthy controls; MCI: mild cognitive impairment; AD: Alzheimer’s disease; n.s.: not significant; Hipp-PC/PCC: hippocampus to PC/PCC tract.