Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria

Figure 1

The evolution and major mechanisms of hypoxic-ischemic brain injury. Arrows indicate HI insult and resuscitation (reperfusion), two fundamental events that cause cerebral damage. Different mechanisms may take a lead in the evolution of brain injury: initiated by the bioenergetics mitochondrial dysfunction, cellular injury is driven by excitotoxicity and oxidative stress, followed by the neuroinflammation. The paper is focused on the proximal to the index event mechanism, an oxidative stress and the role of mitochondrial generation of ROS (see text), modified from [2].