Research Article

Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after Hypoxia/Ischemia

Figure 11

Iba-1+ area on the hippocampus, corpus callosum, caudate-putamen, neocortex, and thalamus is evaluated from 3 hrs to 100 days after hypoxia in the ipsilateral (IL) and contralateral (CL) hemispheres. Reactive microglia is shown as the percentage of the Iba-1+ area (see Section 2 for details). The hippocampus is the most affected region by H/I at 12, 48, 72 hrs and 7 days, as can be observed between IL and CL hemisphere. Significant differences on Iba-1+ area are observed at 12 and 72 hrs after hypoxia in the caudate-putamen and after 12 hrs in the thalamus. Significant differences between IL and CL hemisphere are shown using unpaired t tests, with Welch’s correction if suitable (* , ** , *** ). Individual data and mean ± S.E.M, are represented to show the dispersion in each group.
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