Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after Hypoxia/Ischemia

Figure 7

GFAP staining showing effects of H/I on the caudate-putamen (a–f) and cortex (g–l) of the contralateral (CL) (b, c and h, i) and ipsilateral hemisphere (IL) from 3 hours (hrs) to 14 days after hypoxia (d–f and j–l). Reactive astrocytes are seen in ipsilateral side from 3–72 hrs (d, e) as compared to the P7 control (a) or the contralateral side (b, c). At 14 days after hypoxia the astrocytes reactivity decreases (f). The cortex at 3 hrs (j) shows increase in reactive astrocytes and radial glia-like structures (only at this age) as compared to P7 control (g) and contralateral side (h) with a maximum reactivity at 72 hrs (k) when compared to the respective contralateral side (i); and a decrease in astroglial reactivity is seen at 7 days after hypoxia (l). Scale bar = 100 μm. CP: caudate-putamen; CC: corpus callosum; cx: neocortex.