Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after Hypoxia/Ischemia
Table 1
Injury score grading system. Survival times from 3 to 72 hours after hypoxia.
Hippocampal CA field
(0) No damage
(1) Only one/two patches of neurodegeneration
(2) More than 3 neurodegeneration patches
(3) Most CA1 or CA3 damaged
(4) All CA1 and CA1 damaged
Hippocampal DG
(0) No damage
(1) <40% of DG neurons damaged
(2) Approximately 50% of DG neurons damaged
(3) >60% of DG neurons damaged
Corpus callosum
(0) No changes seen
(1) Increased cellularity in ipsilateral corpus callosum
(2) Increased cellularity in ipsilateral corpus callosum and
swelling
Caudate-Putamen
(0) No damage
(1) <40% of striatal area damaged (usually with increased
cellularity in white matter patches)
(2) Approximately 50% of striatal area damaged
(3) >60% of striatal area damaged
Neocortex
(0) No damage
(1) Scattered neurodegeneration columns in cortex
(2) Neurodegeneration columns in most cortical areas
(3) General neurodegeneration in several areas, all layers
Thalamus
(0) No damage
(1) <40% of thalamic area damaged (only rostral thalamus)
