Research Article

Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after Hypoxia/Ischemia

Table 2

Injury score grading system. Survival times from 7 to 100 days after hypoxia.

Neuronal density in hippocampal CA fields

(0) No reduction
(1) More than 60% of CA neurons remaining
(2) Approximately 50% of CA neurons remaining
(3) Between 10 and 40% of CA neurons remaining
(4) Less than 10% of CA neurons remaining

Hippocampal CA field

(0) No damage
(1) Only one/two patches of neurodegeneration
(2) More than 3 neurodegeneration patches
(3) Most CA1 or CA3 damaged
(4) All CA1 and CA1 damaged

Neuronal density in hippocampal DG

(0) No reduction
(1) More than 60% of DG neurons present
(2) Approximately 50% of DG neurons present
(3) Between 10 and 40% of DG neurons present
(4) Less than 10% of CA neurons remaining

Corpus callosum atrophy

(0) No reduction
(1) More than 60% of tissue remaining (less than 40% atrophy)
(2) Approximately 50% of tissue remaining
(3) Less than 40% of tissue remaining (more than 60% atrophy)

Corpus callosum cellularity

(0) No changes seen
(1) Increased cellularity in corpus callosum
(2) Increased cellularity in corpus callosum and swelling

Caudate-Putamen atrophy

(0) No reduction
(1) More than 60% of tissue remaining (less than 40% atrophy)
(2) Approximately 50% of tissue remaining
(3) Less than 40% of tissue remaining (more than 60% atrophy)

Neocortical atrophy

(0) No reduction
(1) More than 60% of tissue remaining (less than 40% atrophy)
(2) Approximately 50% of tissue remaining
(3) Less than 40% of tissue remaining (more than 60% atrophy)

Thalamic atrophy

(0) No reduction
(1) More than 60% of tissue remaining (less than 40% atrophy)
(2) Approximately 50% of tissue remaining
(3) Less than 40% of tissue remaining (more than 60% atrophy)