Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS

<table>Three major toxic pathways that contribute to neurodegeneration. Nrf2/ARE signaling activation via triterpenoids can reduce oxidative damage, lessen inflammation, and restore mitochondria resulting in more robust motor neurons able to defend themselves against toxic insults.</table>

Neurology Research International

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Figure 1

Figure 1: Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS 