Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS

<table>Schematic representation of major pathways involved in motor neuron death. The Nrf2/ARE signaling pathway is a potential target for blocking multiple death pathways. Green arrows represent neuroprotective pathways, and black arrows point to known neuronal death pathways containing potential cellular targets for antioxidant and anti-inflammatory agents.</table>

Neurology Research International

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Figure 2: Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS 