Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease
Figure 4
(a) Age effect on the longitudinal followup of GMV for the three APOE groups, illustrating the significant interaction between age and the APOE ɛ4. ɛ4 (–/–): noncarriers for the APOE ɛ4 allele, and ɛ4 (+/–): heterozygous for the APOE ɛ4 allele, ɛ4 (+/+): homozygous for the APOE ɛ4 allele (adapted with permission from [30]). (b) Regression of the normalized volume of the prefrontal callosal subregion on age in APOE ε4 carriers (red) and noncarriers (blue). Thick lines show linear regression lines and dotted lines 95% mean confidence intervals of the slope. Formulas denote regression lines. Normalization was done to total intracranial volume (adapted with permission from [31]).
