Review Article

Genetics of Cerebral Vasospasm

Table 2

Summary of preclinical in vivo gene therapy experiments.

GeneReferenceMethodOrganismExpressionEffect

β-galactosidase [53]AdenovirusCanineLeptomeninges, ependyma, and BA adventitia
CGRP[54]AdenovirusRabbitCSF, BA adventitia, and perivascular tissueAttenuation of vasoconstriction
HMOX[55]AdenovirusRatHO-1 mRNA and protein
in BA adventitia
Attenuation of vasoconstriction
eNOS[49]AdenovirusCanineBA adventitiaAttenuation of vasoconstriction
Superoxide dismutase[56]AdenovirusRabbitBA adventitiaAttenuation of vasoconstriction
CGRP[57]ProteinRatAttenuation of vasoconstriction
HMOX[58]ArginineRatAll layers of BAAttenuation of vasoconstriction