Review Article

Mild Cognitive Impairment in Parkinson’s Disease: A Review of Current Concepts

Table 1

Prevalence and cognitive profile of PD-MCI.

AuthorsPopulation characteristicsDomains assessedMCI definitionPrevalence PD-MCICognitive profile found

Aarsland et al., 2009 [67]Community-based incidental cohort, 196 nondemented, drug-naïve PD patientsVerbal memory
Visuospatial ability
Attention, executive function
≥1.5 SD below score in at least 1 of 3 domains18.9%86.5% SD-MCI
 62.2% Nonamnestic
 24.3% Amnestic
13.5% MD-MCI
 2.7% Nonamnestic
 10.8% Amnestic
Foltynie et al.,
2004 [32]
Incident cohort of 142 PD patientsExecutive function
Spatial memory
Pattern recognition memory
≥1 SD below normative data in ≥1 test35.2%58% SD-MCI
 34% Frontostriatal deficits
 24% Temporal lobe deficits
42% MD-MCI (frontostriatal and temporal deficits)
Mamikonyan
et al., 2009 [19]
106 PD patients, convenience sample with intact global cognition based on age- and education-adjusted MMSE scoreMemory
Executive function
Attention
≥1.5 SD below normative data in ≥1 domain29.2%61.3% SD-MCI
 29% Attention
 19.3% Amnestic
 13% Executive
38.7% MD-MCI
Muslimović et al., 2005 [20]115 newly diagnosed PD patients without “global cognitive deterioration” defined as an MMSE score <24Executive function
Memory
Attention
Language
Visuospatial
≥2 SD below normative data on ≥3 neuropsychological tests23.5%MCI subtypes not described

SD-MCI: single-domain mild cognitive impairment. MD-MCI: multiple-domain mild cognitive impairment.