Neurology Research International

Review Article

The Role of Magnesium in the Management of Cerebral Vasospasm

Summary of in vivo animal models of SAH/CVS and magnesium therapy.


Author/date	Animal type	SAH model used	Mg²⁺ administration location	Mg²⁺ administration dose	N treatment/ placebo	CVS assessment modality	Major outcome

Mori et al., 2012 [31]	Canine	Double hemorrhage [32]	Intrathecal	0.5 mL/kg of 15 mMol MgSO₄	7/NA	Angiography	BA, VA diameter significantly increased after injection
Mori et al., 2011 [33]	Canine	Double hemorrhage [32]	Intracisternal	0.5 mL/kg of 15 mMol MgSO₄	7/NA	Angiography	BA, VA, and SCA diameter significantly increased. With adequate CSF Mg level
Mori et al., 2009 [34]	Canine	Double hemorrhage [32]	Intracisternal	0.5 mL/kg of 15 mMol MgSO₄	10/NA	Angiography	BA, VA, and SCA diameter significantly increased
Mori et al., 2008 [35]	Rat	Double hemorrhage [32]	Intracisternal	1.5 L/min for 30 minutes of 10 mMol MgSO₄	8/6	Autoradiographic measurement of cerebral blood flow	Mg²⁺ group showed improved cerebral blood flow in 12/16 locations
MacDonald et al., 2004 [36]	Primate	Single hemorrhage [37]	IV	−0.086 g/kg bolus −0.028 g/kg/day	5/5	Angiography	No angiographic evidence of MgSO₄ effect on CVS
van den Bergh et al., 2002 [24]	Rat	Sheffield model [38]	IV	90 mg/kg MgSO₄	14/19	N/A	Pretreatment with MgSO₄ reduces the size of SAH-induced ischemic damage
Ram et al., 1991 [39]	Rat	Single hemorrhage [37]	Group 1: topical Group 2: IV	Group 1: 10 mEq/L Group 2: not stated	Group 1: 30 Group 2: 20 Placebo: 10	Computerized image analysis of basilar artery	Group 1: BA dilated to 150% of baseline Group 2: BA dilated to 75% of baseline