Review Article

Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review

Table 3

Proteomic studies.

Pediatric studiesSampleCollection; followupOutcomeResults

Delahanty et al., 2005 [35]58 ED patientsED; 6 wksDiagnosisHigh cortisol and epinephrine predicted acute PTSD symptoms.
Ostrowski et al., 2007 [36]54 ED patientsED; 6 wks, 7 mosDiagnosisHigh cortisol predicted acute PTSD symptoms and PTSD onset in boys.
Pervanidou et al., 2007 [37]56 MVA patients (9 = PTSD)ED; 1, 6 mosDiagnosisHigh cortisol and IL-6 predicted PTSD onset.

Adult studiesSampleCollection; followupOutcomeResults

Resnick et al., 1995 [38]37 rape survivors (19 = PTSD)ED; 17–157 daysDiagnosisLow cortisol in previously assaulted women predicted PTSD onset.
Yehuda et al., 1998 [39]20 rape survivors (11 = PTSD)ED; 27–157 daysDiagnosisCortisol and MHPG did not predict PTSD onset.
Delahanty et al., 2000 [40]99 MVA patients (9 = ASD)ED; 1 moDiagnosisLow cortisol predicted acute PTSD symptoms.
Bonne et al., 2003 [41]21 ED patients (8 = PTSD)1 wk; 6 mosDiagnosisCortisol did not predict PTSD onset.
Heinrichs et al., 2005 [42]43 firefighters (7 = PTSD at 2 yrs)Training; 6, 9, 12, 24 mosSymptom reportCortisol and CA did not predict PTSD onset.
McFarlane et al., 1997 [43] 40 MVA patients (7 = PTSD)ED; 2, 10 days and 6 mosDiagnosisLow cortisol predicted PTSD onset.
Ehring et al., 2008 [44]53 MVA patients (5 = PTSD)ED; 2 wks, 6 mosDiagnosisLow cortisol predicted PTSD onset.
Shalev et al., 2008 [45]; Videlock et al., 2008 [46]155 ED patients (31 = PTSD)ED; 10 days, and 1, 5 mosDiagnosisCortisol, ACTH, GR, and NE did not predict PTSD onset.
Cohen et al., 2011 [47]48 orthopedic patients, 13 HCAt hospitalization; 1 moSymptom reportHigh IL-8 and low TGF- predicted acute PTSD symptoms.
van Zuiden et al., 2011 [48]68 service members, (34 = PTSD)Prior; following deploymentSymptom reportHigh GR predicted PTSD onset.