Review Article

Measuring Comorbidity in Cardiovascular Research: A Systematic Review

Table 2

Demographics of the studies by diagnosis.

AMIHFStroke

Number of studies8 [1724] 11 [2535]7 [3642]

Publication years1997 [22]–2008 [17, 20]1997 [25]–2009 [35]1995 [38]–2009 [42]

Journal typeCardiac [20, 22, 24], nephrology [19], general medicine [21], nursing [23], psychology [17], and geriatric [18]Cardiac [25, 2932, 34, 35], psychology [26, 33], general medicine [27], and geriatric [28].Neurology/stroke [36, 3942], cardiology [37], and psychology [38]

Author disciplineMedicine [18, 19, 21, 24], medicine plus another discipline [17, 20, 22], or nursing [23]Medicine [2527, 2932, 34, 35], medicine plus another discipline [33], or nursing [28]Medicine [3642]

Country of studyUSA except one [22]USAUSA

Study question related to comorbidity3 [17, 19, 21]4 [25, 26, 31, 33]3 [36, 38, 40]

Used a comorbidity instrumentCCI [17]CCI [25], Duke Severity of Illness Checklist [26], Geriatric Depression Scale [26], and Beck Depression Inventory [31, 33]Hamilton Depression Rating Scale [36]

Main outcomesMortality [18, 19, 21, 22], morbidity [20, 21, 23, 24], and disability [17]Mortality [25, 27, 31], disability [26, 28, 33], QoL [28], and health service utilization [25, 2830, 32, 34]Morbidity [3840, 42], QoL [37, 38], and health service utilization [41]

CCI: Charlson Comorbidity Index, QoL: quality of life.