Research Article

Epigenetic Markers of Renal Function in African Americans

Table 2

Top 30 CpG sites most strongly associated with eGFR (Model 1).

Genetic description -value information
CpG SiteChrGeneGene product -value mean (SD) -value

cg002269236FGD2 FYVE; RhoGEF and PH domain containing 22.9 (0.4)−8.8
cg1747110219FUT3 Galactoside 3(4)-L-fucosyltransferase0.7 (0.3)12.4
cg1226178610ADIRF Adipogenesis regulatory factor1.2 (0.3)12.6
cg1091760216HSD3B7 3 Beta-hydroxy-delta 5-C27-steroid oxidoreductase0.4 (0.4)8.3
cg046625948EPB49 Erythrocyte membrane protein band 4.9 (dematin)−0.8 (0.4)9.6
cg1512130422IGL2 Immunoglobulin lambda locus1.9 (0.3)−10.7
cg248577211RHD Rh blood group D antigen isoform 10.4 (0.4)8.5
cg1468827217FN3KRP Fructosamine-3-kinase-related protein−0.2 (0.3)11.3
cg1976127317HCKID Casein kinase 1; delta isoform 1−2.0 (0.3)10.9
cg2409225320YTHDF1 YTH domain family; member 1−1.2 (0.3)11.0
cg1012692319NKG7 Natural killer cell group 7 sequence−0.2 (0.5)6.6
cg255385718FLJ46365 Hypothetical protein LOC401459−0.7 (0.3)10.8
cg111205511CHD1L Chromodomain helicase DNA binding protein 1-like−0.9 (0.4)8.9
cg005639329PTGDS Prostaglandin H2 D-isomerase0.3 (0.3)9.7
cg1628066711BLR1 Burkitt lymphoma receptor 1 isoform 12.1 (0.4)−9.4
cg1212511716GPR97 G protein-coupled receptor 97−0.8 (0.5)7.0
cg0182037412LAG3 Lymphocyte-activation protein 3 precursor−0.7 (0.3)10.2
cg098096721EDARADD EDAR-associated death domain isoform B−0.4 (0.4)7.5
cg1485941710PTPRE Protein tyrosine phosphatase; receptor type; E isoform 2−1.7 (0.4)9.1
cg1815283017TNFRSF13B Tumor necrosis factor receptor 13B2.6 (0.3)−10.8
cg0874339220GSS Glutathione synthetase−2.5 (0.4)8.3
cg2684202419KLF2 Kruppel-like factor 2−2.9 (0.4)−8.2
cg074268481S100A3 S100 calcium binding protein A32.1 (0.3)−9.5
cg152976502DKFZP566N034 Hypothetical protein LOC81615−0.04 (0.3)10.8
cg1758934118SLC14A1 Rsolute carrier family 14 (urea transporter), member 10.03 (0.3)9.3
cg2112694319CEACAM6 Carcinoembryonic antigen-related cell adhesion molecule 6 (nonspecific cross reacting antigen)−0.8 (0.4)6.9
cg0740845619PGLYRP2 Peptidoglycan recognition protein L precursor−0.2 (0.4)8.3
cg2526871814PSME1 Proteasome activator subunit 1 isoform 10.3 (0.2)13.5
cg0870030619LRP3 Low-density lipoprotein receptor-related protein 3−0.04 (0.3)9.7
cg028639473NR1I2 Pregnane X receptor isoform 2−0.4 (0.5)6.7

Model 1: .