Epigenetic Markers of Renal Function in African Americans

Table 3

Univariable and multivariable linear regression for eGFR.

Risk factors (𝑁=972)	Univariable model (Model 4)^a		Multivariable model (Model 5)^b
	𝛽1 (𝑃 value)	𝑅^2	𝛽𝑘 (𝑃 value)	𝑅^2
Homocysteine (𝜇mol/L)	−2.0 (4.9𝐸−48)	0.1965	−1.7 (7.6𝐸−36)	0.2827
Age (years)	−1.0 (8.9𝐸−35)	0.1445	−0.8 (1.1𝐸−21)
Fibrinogen (mg/dL)	−0.03 (0.0009)	0.0114	−0.02 (0.0160)
Serum cholesterol (mg/dL)	−0.06 (0.0002)	0.0140	−0.03 (0.0263)
Sex^c	2.8 (0.0560)	0.0038	—	—
Height (cm)	−0.1 (0.1137)	0.0026	—	—
Weight (kg)	−0.03 (0.4851)	0.0005	—	—
Waist circumference (cm)	−0.06 (0.1834)	0.0018	—	—
Hip circumference (cm)	−0.01 (0.9113)	0.0000	—	—
Body mass index (kg/m^2)	0.02 (0.8402)	0.0000	—	—
C-reactive protein (mg/L)	0.5 (0.3814)	0.0008	—	—
Serum glucose (mg/dL)	0.02 (0.1869)	0.0018	—	—
Serum triglycerides (mg/dL)	−0.03 (0.0150)	0.0061	—	—
Systolic blood pressure (mm Hg)	−0.08 (0.0072)	0.0074	—	—
Diastolic blood pressure (mm Hg)	0.09 (0.1217)	0.0025	—	—
Combined high density lipoprotein (mg/dL)	0.02 (0.5416)	0.0004	—	—
Hypertension^d	−6.4 (0.0002)	0.0141	—	—
Type 2 diabetes^e	−1.2 (0.3992)	0.0007	—	—

aModel 2: eGFR_𝑖=𝛽₀+𝛽₁⋅RiskFactor_𝑖+𝜀_𝑖.
bModel 5: eGFR_𝑖=𝛽₀+∑^𝑝_𝑚=1𝛽_𝑚⋅RiskFactor_𝑚𝑖+𝜀_𝑖, where 𝑝 is the number of risk factors.
cFemale = 1, male = 0.
dHypertension = 1, no hypertension = 0.
eType 2 diabetes = 1, no type 2 diabetes = 0.