Research Article
[Retracted] One-Pot Synthesis of Pyrrolidine-2-ones from Erythruronolactone and Amine
Table 1
Result of the preparation of protected polyhydroxylated pyrrolidinone iminosugar (7).
| Productsa | R | Yields | 7a-p/7a′-p′ |
| (5a′, 5a) | Pyridin-2yl | 87 | 40/60 | (5b′, 5b) | 2-Methylpyridin-2-yl | 77 | 45/55 | (5c′, 5c) | 4-Methylpyridin-2-yl | 56 | 33/67 | (5d′, 5d) | 2-Ethen-2-yl | 77 | 36/63 | (5e′, 5e) | 2,2-Diethoxyeth-2-yl | 55 | 50/50 | (5f′, 5f) | 2,2-Dimethoxymeth-2-yl | 56 | 45/55 | (5g′, 5g) | 2-Ethyn-2-yl | 77 | 53/47 | (5h′, 5h) | Ethyl | 60 | 50/50 | (5i′,5i) | Propyl | 50 | 67/33 | (5j′, 5j) | Butyl | 66 | 50/50 | (5k′, 5k) | Pentyl | 50 | 50/50 | (5l′, 5l) | Hexyl | 50 | 50/50 | (5m′, 5m) | Heptyl | 65 | 67/33 | (5n′, 5n) | Octyl | 50 | 50/50 | (5o′, 5o) | Ph | 72 | 21/79 | (5p′, 5p) | 4-Methylmorpholin-2-yl | 60 | 22/78 |
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aMixture of epimers.
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