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Organic Chemistry International
Volume 2012 (2012), Article ID 515092, 7 pages
http://dx.doi.org/10.1155/2012/515092
Research Article

Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

1Department of Applied Chemistry, Priyadarshini College of Engineering and Technology, Hingna, Maharashtra, Nagpur 440019, India
2Department of Chemistry, Government Institute of Science, Civil Lines, Maharashtra, Nagpur 440001, India

Received 13 June 2012; Accepted 14 August 2012

Academic Editor: Robert Batey

Copyright © 2012 Nikhil V. Suramwar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple and efficient method for N-arylation of 1,2,4-triazole at room temperature was described by the use of predominant (111) facet CuO nanoparticles as a catalyst in ligand-free condition. The catalyst was recyclable, and a variety of substrates give N-arylation product in high yield with short period of reaction time. The wide scope of this catalyst led us to investigate transformations involving less-reactive nitrogen nucleophiles, such as imidazole and pyrazoles. We were pleased to find that various derivatives of azoles were effectively coupled with aryl iodide to afford the desired N-arylated product in excellent yield.