Table 2: Optimization of reaction condition for the N-arylation of 1,2,4-triazole with iodobenzene.

EntrySolventBaseReaction time (h)(Isolated yield)a

1TolueneK2CO31265%
2CH3CNK2CO31240%
3CH3OHK2CO31225%
4CHCl3K2CO31215%
5DMFK2CO3284%
6DMFK2CO3884%
7DMFCS2CO3545%
8DMFt-BuONa555%
9DMFNaOH535%
10DMFRb2CO3475%

aIsolated yield.