Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

Table 2

Optimization of reaction condition for the N-arylation of 1,2,4-triazole with iodobenzene.

Entry	Solvent	Base	Reaction time (h)	(Isolated yield)^a
1	Toluene	K2CO3	12	65%
2	CH3CN	K2CO3	12	40%
3	CH3OH	K2CO3	12	25%
4	CHCl3	K2CO3	12	15%
5	DMF	K2CO3	2	84%
6	DMF	K2CO3	8	84%
7	DMF	CS2CO3	5	45%
8	DMF	t-BuONa	5	55%
9	DMF	NaOH	5	35%
10	DMF	Rb2CO3	4	75%

^aIsolated yield.