Environmentally Benign Mortar-Pestle-Induced Acylation and O-Alkylation of Aromatic and Heteroaromatic Compounds under Solvent-Free Micellar Conditions and Computation of Their Drug Likeliness Properties

Table 2

Mortar-pestle-induced micellar mediated O-alkylation of hydroxy pyridines under solvent-free conditions.

Reactants		CTAB; (1.5 hr)	SDS; (2.0 hr)	TX-100; (2.5 hr)
1	2	% yield	% yield	% yield
2-Hydroxy pyridine	MeOH	89	85	86
	EtOH	90	87	87
	1-PrOH	90	86	82
	2-PrOH	90	87	89
3-Hydrox pyridine	MeOH	91	85	82
	EtOH	89	84	81
	1-PrOH	85	83	80
	2-PrOH	89	85	79
4-Hydroxy pyridine	MeOH	91	88	81
	EtOH	88	85	83
	1-PrOH	88	83	82
	2-PrOH	89	84	81
5-Bromopyrimidin-2-ol	MeOH	91	87	89
	EtOH	89	87	87
	1-PrOH	89	86	86
	2-PrOH	91	84	86
6-Hydroxypicolinaldehyde	MeOH	92	88	89
	EtOH	88	86	89
	1-PrOH	87	85	84
	2-PrOH	88	87	86