Environmentally Benign Mortar-Pestle-Induced Acylation and O-Alkylation of Aromatic and Heteroaromatic Compounds under Solvent-Free Micellar Conditions and Computation of Their Drug Likeliness Properties

Table 5

Reaction of 1-halo-2-methoxynaphthalene (2 mmol) With 2g (2 mmol) using CTAB/CTAC (various amounts) as a catalyst.

Naphthalene	CTAB/CTAC; (mmol)	Time; (min)	Conversion of 1 (%)
1a	0.02	60	70
		80	73
		100	75
		120	80
1a	0.04	60	72
		80	78
		100	82
		120	85
1a	0.06	60	74
		80	80
		100	84
		120	86
1a	0.08	60	76
		80	83
		100	86
		120	90
1a	0.10	60	80
		80	85
		100	89
		120	93
1b	0.02	60	70
		80	75
		100	78
		120	83
1b	0.04	60	72
		80	75
		100	79
		120	85
1b	0.06	60	74
		80	79
		100	80
		120	87
1b	0.08	60	76
		80	81
		100	83
		120	89
1b	0.10	60	80
		80	85
		100	88
		120	93