Environmentally Benign Mortar-Pestle-Induced Acylation and O-Alkylation of Aromatic and Heteroaromatic Compounds under Solvent-Free Micellar Conditions and Computation of Their Drug Likeliness Properties

Table 7

Drug likeness of compounds.

S. number	6-Acyl-1-halo-2-methoxynaphthalene	GPCRL	ICM	KI	NRL
1	1-(1-Bromo-2-methoxynaphthalen-6-yl)ethanone	−0.56	−0.51	−0.71	−0.57
2	1-(1-Bromo-2-methoxynaphthalen-6-yl)pentan-1-one	−0.18	−0.36	−0.42	−0.20
3	1-(1-Bromo-2-methoxynaphthalen-6-yl)hexan-1-one	−0.13	−0.34	−0.35	−0.14
4	1-(1-Bromo-2-methoxynaphthalen-6-yl)-4-methylpentan-1-one	−0.14	−0.33	−0.39	−0.14
5	1-(1-Bromo-2-methoxynaphthalen-6-yl)-5-methylhexan-1-one	−0.09	−0.31	−0.34	−0.08
6	1-(1-Bromo-2-methoxynaphthalen-6-yl)-3,3-dimethylbutan-1-one	−0.19	−0.27	−0.46	−0.32
7	1-(1-Bromo-2-methoxynaphthalen-6-yl)-2-phenylethanone	−0.06	−0.30	−0.24	−0.05
8	1-(1-Chloro-2-methoxynaphthalen-6-yl)ethanone	−0.50	−0.22	−0.67	−0.49
9	1-(1-Chloro-2-methoxynaphthalen-6-yl)pentan-1-one	−0.13	−0.12	−0.39	−0.14
10	1-(1-Chloro-2-methoxynaphthalen-6-yl)hexan-1-one	−0.08	−0.11	−0.32	−0.08
11	1-(1-Chloro-2-methoxynaphthalen-6-yl)-4-methylpentan-1-one	−0.10	−0.10	−0.37	−0.08
12	1-(1-Chloro-2-methoxynaphthalen-6-yl)-5-methylhexan-1-one	−0.04	−0.09	−0.31	−0.02
13	1-(1-Chloro-2-methoxynaphthalen-6-yl)-3,3-dimethylbutan-1-one	−0.14	−0.04	−0.43	−0.26
14	1-(1-Chloro-2-methoxynaphthalen-6-yl)-2-phenylethanone	−0.02	−0.10	−0.21	0.00
STD	Naproxen	−0.06	0.00	−0.36	0.18

GPCR: ligand, ICM: Ion channel modulator, KI: Kinase inhibitor, NRL: Nuclear receptor ligand.