Catalytic Synthesis of 3-Methyl-1-phenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-dione Derivatives Using Cerium Oxide Nanoparticles as Heterogeneous Catalyst in Green Conditions

Table 3

Temperature optimization for the synthesis of 3-methyl-1,4-diphenyl-1H-benzo[g]pyrazolo[3,4-b]quinoline-5,10-dione (4a), in the presence of water as green solvent and using cerium oxide nanoparticles (CONPs) catalyst.

Entry	Temp (°C)	Time (h)	^aYield (%)
1	Room (25)	12	40
2	35	9	55
3	45	8.5	64
4	65	7	73.5
5	85	6	80
6	Reflux	4	94.5

aIsolated yield.