Research Article
Proline Based Chiral Ionic Liquids for Enantioselective Michael Reaction
Table 1
Enantioselective Michael reaction of trans-β-nitrostyrene with cyclohexanone in the presence of 1aa.
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All reactions were carried out using 20 equivalent ketone and 1 equivalent trans-β-nitrostyrene moieties in the presence of 1a and additive (5 mol%) under neat conditions at room temperature for 48 h. bIsolated yield. cDetermined by 1H NMR spectroscopy. dDetermined by chiral HPLC analysis (CHIRALPAK AD-H). eSalicylic acid. fTrifluoroacetic acid. |