Obstetrics and Gynecology International
Volume 2009 (2009), Article ID 364843, 8 pages
doi:10.1155/2009/364843
Clinical Study

Recombinant Activated Factor VII (rFVIIa) in the Management of Major Obstetric Haemorrhage: A Case Series and a Proposed Guideline for Use

1Department of Haematology, The Newcastle upon Tyne Hospitals NHS Trust, Freeman Hospital, Freeman Road, High Heaton, Newcastle-upon-Tyne NE7 7DN, UK
2Department of Obstetrics, The Newcastle upon Tyne Hospitals NHS Trust, Newcastle-upon-Tyne NE1 4LP, UK

Received 19 July 2009; Revised 14 October 2009; Accepted 1 December 2009

Academic Editor: Marc J. N. C. Keirse

Copyright © 2009 Charlotte Bomken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Why mothers die,” A report on confidential enquiries into maternal deaths in the UK 2000–2002. The Department of Health. Confidential Enquiry into maternal and child health.
  2. R. P. Dutton, M. McCunn, M. Hyder, et al., “Factor VIIa for correction of traumatic coagulopathy,” Journal of Trauma, vol. 57, no. 4, pp. 709–719, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Mittal and H. G. Watson, “A critical appraisal of the use of recombinant factor VIIa in acquired bleeding conditions,” British Journal of Haematology, vol. 133, no. 4, pp. 355–363, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. A. Mayo, M. Misgav, Y. Kluger, et al., “Recombinant activated factor VII (NovoSevenTM): addition to replacement therapy in acute, uncontrolled and life-threatening bleeding,” Vox Sanguinis, vol. 87, no. 1, pp. 34–40, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. N. M. O'Connell, D. J. Perry, A. J. Hodgson, D. F. O'Shaughnessy, M. A. Laffan, and O. P. Smith, “Recombinant FVIIa in the management of uncontrolled hemorrhage,” Transfusion, vol. 43, no. 12, pp. 1711–1716, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. J. W. Eikelboom, R. Bird, D. Blythe, et al., “Recombinant activated factor VII for the treatment of life-threatening haemorrhage,” Blood Coagulation & Fibrinolysis, vol. 14, no. 8, pp. 713–717, 2003. View at Scopus
  7. A. Aggarwal, V. Malkovska, J. P. Catlett, and K. Alcorn, “Recombinant activated factor VII (rFVIIa) as salvage treatment for intractable hemorrhage,” Thrombosis Journal, vol. 2, article 9, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. U. Martinowitz and M. Michaelson, “Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force,” Journal of Thrombosis and Haemostasis, vol. 3, no. 4, pp. 640–648, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. J. Ahonen, R. Jokela, and K. Korttila, “An open non-randomized study of recombinant activated factor VII in major postpartum haemorrhage,” Acta Anaesthesiologica Scandinavica, vol. 51, no. 7, pp. 929–936, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. J. Ahonen and R. Jokela, “Recombinant factor VIIa for life-threatening post-partum haemorrhage,” British Journal of Anaesthesia, vol. 94, no. 5, pp. 592–595, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. F. W. Bouwmeester, A. R. Jonkhoff, R. H. M. Verheijen, and H. P. van Geijn, “Successful treatment of life-threatening postpartum hemorrhage with recombinant activated factor VII,” Obstetrics and Gynecology, vol. 101, no. 6, pp. 1174–1176, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Price, J. Kaplan, and G. Skowronski, “Use of recombinant factor VIIa to treat life-threatening non-surgical bleeding in a post-partum patient,” British Journal of Anaesthesia, vol. 93, no. 2, pp. 298–300, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. S. Sobieszczyk, G. H. Bręborowicz, V. Platicanov, S. Tanchev, and C. M. Kessler, “Recombinant factor VIIa in the management of postpartum bleeds: an audit of clinical use,” Acta Obstetricia et Gynecologica Scandinavica, vol. 85, no. 10, pp. 1239–1247, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. L. P. Pepas, M. Arif-Adib, and R. A. Kadir, “Factor VIIa in puerperal hemorrhage with disseminated intravascular coagulation,” Obstetrics and Gynecology, vol. 108, no. 3, part 2, pp. 757–761, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. F. Boehlen, M. A. Morales, P. Fontana, B. Ricou, O. Irion, and P. de Moerloose, “Prolonged treatment of massive postpartum haemorrhage with recombinant factor VIIa: case report and review of the literature,” British Journal of Obstetrics and Gynaecology, vol. 111, no. 3, pp. 284–287, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Macphail and K. Talks, “Massive post-partum haemorrhage and management of disseminated intravascular coagulation,” Current Obstetrics and Gynaecology, vol. 14, no. 2, pp. 123–131, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Kwee, M. L. Bots, G. H. A. Visser, and H. W. Bruinse, “Emergency peripartum hysterectomy: a prospective study in the Netherlands,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 124, no. 2, pp. 187–192, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. D. Habek and R. Becarevic, “Emergency peripartum hysterectomy in a tertiary obstetric center: 8-year evaluation,” Fetal Diagnosis and Therapy, vol. 22, no. 2, pp. 139–142, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. T. T. Biss and J. P. Hanley, “Recombinant activated factor VII (rFVIIa/NovoSeven®) in intractable haemorrhage: use of a clinical scoring system to predict outcome,” Vox Sanguinis, vol. 90, no. 1, pp. 45–52, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. F. Moscardo, F. Perez, J. de La Rubia, et al., “Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII,” British Journal of Haematology, vol. 114, no. 1, pp. 174–176, 2001. View at Publisher · View at Google Scholar · View at Scopus