The Potential Use of Intrauterine Insemination as a Basic Option for Infertility: A Review for Technology-Limited Medical Settings

Table 1

Motile sperm concentration, normal morphology, and IUI outcome.

Author	Year	Design (prospective or retrospective)	Number of infertile patients	Number of insemination cycles	IMSC (million)	Normal morphology	IUI outcome	Total motile sperm count*10/6 (before wash)
Ombelet et al.	1997	Retrospective	373	792	<1	<4%	0% CF
					<1	>4%	7.8%
					>1	>4%	15%
Van Voorhis et al.	2001	Retrospective	1,039	3,479			PR 2.3%	<10
							PR 9%	>10
Cohlen et al.	1998	Prospective	74	308	<1		PR 2.6%
					>1		PR 11.2%
Wainer et al.	2004	Retrospective	889	2,564	<1	>30%	PR 3.1%
					2–5		PR 12%
Dodson & Haney	1991	Retrospective	371	808	<1		CF 0%
					1–5		CF 17%
Horvath et al.	1989	Prospective	232	451	<1		CF 2.6%
					>10		CF 11.6%
Berg et al.	1997	Retrospective	902	3,037	0.8–1.2		PRcy 8.2%
					>5		10%
Miller et al.	2002	Prospective	438	1,114	<10		CF 1%
					10–20		CF 7.4%
					>20		CF 12.4%
Irianni et al.	1993	Retrospective	129	208	>4.7		PR 14%
Toner et al.	1994	Prospective	126	395	104	9%	PRcy 9%
Lindheim et al.	1996	Retrospective	42			<4%	PRcy 1%
						>4%	PRcy 19%
Montanaro Gauci et al.	1999	Retrospective	273	522		<4%	PRcy 2.6%
						5–14%	11%
						>14%	24%
Shibahara et al.	2004	Prospective	160	682		>15%	PRcy 15%
Hauser et al.	2001	Prospective	108	264		<4%	4-PRcp 11%
						14%	36%
						>14%	50%
Lee et al.	2002	Prospective	209	244		<4%	PRcy 3.8%
						4–9%	18.5%
						>9%	30%
Dickey et al.	1999	Retrospective	1,841	4,056		<5%	PRcy 0%
						>5%	11%
Dickey et al.	1999	Retrospective	1,841	4,056			PRcy 2.3%	<5
							8.5%	>5

CF: Cycle fecundity; IMSC: Inseminated motile sperm count; PR: Overall pregnancy rate; PRcy: Pregnancy rate per cycle; PRcp: Pregnancy rate per couple.