About this Journal Submit a Manuscript Table of Contents
Obstetrics and Gynecology International
Volume 2011 (2011), Article ID 609370, 7 pages
http://dx.doi.org/10.1155/2011/609370
Review Article

Polycystic Diseases in Visceral Organs

Department of Pharmacology, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue, MS 1015, Toledo, OH 43614, USA

Received 25 July 2011; Accepted 27 September 2011

Academic Editor: J. L. Simpson

Copyright © 2011 Shakila Abdul-Majeed and Surya M. Nauli. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory roles of cilia in maintaining healthy cellular state. In particular, dysfunctional cilia have been implicated in a large number of diseases mainly characterized by the presence of fluid-filled cysts in various organs. Aside from polycystic kidney disease (PKD), however, the roles of cilia in polycystic liver disease (PLD), polycystic pancreas disease (PPD), and polycystic ovarian syndrome (PCOS) are still very vague. In addition, although gender and sex hormones are known to regulate cyst formation, their roles in regulating physiological functions of cilia need to be further explored.