609370.fig.002
Figure 2: Mechanosensory cilia function involves calcium signal transduction. Mechanosensory cilia require functional polycystin complex. Fluid-flow-induced cilia bending will activate polycystin complex. This will mobilize calcium ions (Ca2+) influx from the extracellular matrix (ECM) into the cell. Calcium-induced calcium release will further activate various calcium-dependent proteins to maintain proper organogenesis.