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Figure 4: Gene linkage map of the genes at the node of the transitional zone (marked by an asterisk in Figure 1(a)) constructed by Genomatix BiblioSphere. The overexpressed genes coded in red, underexpressed in yellow, and unchanged in green were all combined and filtered at the B0 filter level. The color coding reflects the gene expression heterogeneity among specimens and the power of parsimony phylogenetics to reveal the dynamic disease process. The biosignature is centered around ESR2 as the potential major player influencing the gene network and change to endometriosis.