Clinical Study

Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis

Table 1

Gene list of over- and underexpressed genes summarized by function. These dichotomously expressed genes reflect the gene expression heterogeneity among specimens.

FunctionGene symbol

Cell cycleCAV1CCNA2DDR2E2F2GPC3
GPC6GTSE1IFI16MAD2L2MAP2K6
NCAPHPTPN21PTPN3RBBP8RPS6KA3
SLBPTGFBR3TP53TRMU

Cell adhesion and migrationCDH1CDH3CLDN3CLDN4CLEC10A
HOXA10HOXA11HOXB2HOXB3HOXB4
HOXB5HOXB6HOXB7HOXB8HOXC4
HOXC5HOXC6IQGAP1LGALS8TGFBR3

ApoptosisIHPK2BIRC5BNIP3LBOKFAIM3
IL24MAP2K6MAPK10PAK6RBMS3
TP53TPD52L1WDR26

Infertility/fertilityLEFTY2PAK6SPA17SPAG1

ImmunityBOCBST2CD40CEACAM1CLEC10A
ICAM1IGSF11JAK3NR3C1PVRL3
RIPK2SIGLEC1SIGLEC11TNFSF13BTSC22D3

Cell structureACTA2ACTG2ARHGAP25ARL6IP5CLDN5
CNKSR1COL10A1COL3A1COL4A3COL8A1
DCLK1EMCNESR1HS6ST2IQGAP1
ITGA11ITGB8KRT19LAMA5LAMB2
LAMC2LAMC3LTBP2MMP26NID2
PAK6PCOLCEPPFIBP1SGCESIRPA
SPC25SPTBN1TGFBR3TNS1VAPA

IronFTL

Angiogenesis/invasionADAMTS3ANGPT1ANGPTL1C9ORF47ITGA7
NRP1NRP2PROK1S1PR3TIMP1
TIMP4

ProliferationADAMTS18CLDN11CREG1DOK5DUSP4
EHFGPC6IFI16MAP3K1MAPRE2
NTRK2PTPRBTRAF4

Steroid hormone regulationAKR1C1AKR1C2CPECRYMCYP11A1
CYP2J2CYP39A1DIO2ESR1FST
HSD11B1NR3C1PLTPPTGER3PTGFR
PTGISRORASTARVIPR2

Tumor suppressorDIRAS3E2F2FABP3LYVE1SMARCB1

CarcinogenesisDOCK4ERBB3ESR1FN1HLA-C
JAZF1IGKIGKCNBR1RECK
TBX2

Stress responseBDNF