Clinical Study
Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis
Table 2
Gene list summarizing the biosignature of the eutopic clade.
| Function | Gene symbol |
| Cell cycle | CDKN2A | PTGS2 | EGFR | MDM2 | F2 | BRCA2 | BTRC | | | |
| Clotting/vascular integrity | F2 | NOS1 | RHOA | MMP1 | SP1 |
| Cell adhesion and migration | CD36 | RHOA | MMP1 | EGFR | CDKN2A | F2 | JAG1 | PTGS2 | | |
| Apoptosis | MDM2 | BAT3 | BCL2L1 | IL17A | RARA | CASP3 | BAD | AKAP13 | PTGS2 | EGFR | CDKN2A | F2 | RHOA | | |
| Infertility/fertility | MMP1 | EGFR | BRCA2 | BCL2L1 | PTGS2 |
| Immunity | CD19 | CD68 | IL17A | IL1RN | RARA | CMA1 | CDKN2A | BAD | CD36 | CNR2 | MMP1 | | | | |
| Inflammation | IL1RN | IL17A | CMA1 | PTGS2 | F2 | CNR2 | | | | |
| Cell structure | KCNJ5 | TPM3 | RHOA | EGFR | F2 | MMP1 | | | | |
| Carcinogenesis | TPM3 | KLK3 | EGFR | | |
| Angiogenesis/invasion | JAG1 | KLK3 | PTGS2 | | |
| Cell proliferation | EGFR | CDKN2A | F2 | BRCA2 | MDM2 | BTRC | BAD | BCL2L1 | JAG1 | |
| Organogenesis | SP1 | TPM3 | MMP1 | EGFR | BCL2L1 | DRD2 | JAG1 | | | |
| Steroid hormone regulation | RARA | RHOA | | | |
| Tumor suppressor | MDM2 | BAT3 | BRCA2 | NOS1 | |
| Stress response | FADS1 | NOS1 | RHOA | | |
| Protein ubiquitination | BTRC | MDM2 | | | |
| Lipid metabolism | ABCA1 | FADS1 | PTGS2 | CD36 | |
| Dopamine receptor | DRD2 | | | | |
| Ion transport | KCNJ5 | SP1 | RARA | DRD2 | PTGS2 |
| Glucose homeostasis | BAD | RHOA | | | |
| Cell debris removal | CD68 | CD36 | | | |
| Water and ion balance | DRD2 | | | | |
| Cell differentiation | FADS1 | JAG1 | SP1 | RHOA | |
|
|