Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer

Table 3

Serum HA, SHAP-HA complex, MMP-2, MMP-9, TIMP-1, and UTI in relation to the depth of myometrial invasion, histological grade, and lymph-vascular space involvement in patients with endometrial cancer.

	𝑛	HA; (ng/mL)	SHAP-HA complex; (U/mL)	UTI; (μg/mL)	MMP-2; (ng/mL)	MMP-9; (ng/mL)	TIMP-1; (ng/mL)
Myometrial invasion
Less than half	30	236.94±145.14	2.151±2.030	5.737±13.679	720.03±197.67	598.90±439.17	199.27±81.09
More than half	20	565.18±200.37	5.009±3.888	8.905±17.080	679.80±158.96	942.65±582.89	260.60±117.41
		𝑃<0.0001	𝑃=0.0014	𝑃=0.4713	𝑃=0.4508	𝑃=0.0215	𝑃=0.0336
Histological grade
G1/G2	40	295.39±180.95	2.443±2.397	4.422±11.565	699.50±186.84	694.58±504.76	209.40±92.94
G3	10	659.63±191.00	6.698±3.883	17.330±22.462	721.70±172.34	903.70±594.45	281.40±115.21
		𝑃<0.0001	𝑃<0.0001	𝑃=0.0136	𝑃=0.7347	𝑃=0.2635	𝑃=0.0421
Lymph-vascular space involvement
Absent	28	247.75±147.98	2.340±2.838	2.107±1.767	682.32±185.10	575.71±328.58	179.75±36.44
Present	22	521.57±234.18	4.508±3.304	13.236±21.246	731.46±179.66	940.91±651.32	279.86±126.95
		𝑃<0.0001	𝑃=0.0161	𝑃=0.0080	𝑃=0.3500	𝑃=0.0129	𝑃=0.0002

Values are shown as mean ± SD.