About this Journal Submit a Manuscript Table of Contents
Obstetrics and Gynecology International
Volume 2011 (2011), Article ID 949302, 6 pages
Clinical Study

Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women

1Division of Obstetrics and Gynecology, General Public Teaching Hospital Korneuburg, 2100 Korneuburg, Austria
2Instituto para la Salud de la Mujer, Facultad de Ciencias Médicas, Universidad Católica de Santiago Guayaquil, 196 Guayaquil, Ecuador
3Study Center Med XIX, Grinzingerstr 83, 1190 Vienna, Austria
4Division of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria

Received 7 August 2011; Accepted 31 August 2011

Academic Editor: Faustino R. Pérez-López

Copyright © 2011 Markus Lipovac et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Evaluate in postmenopausal women the effect of red clover extract (RCE) isoflavones over subjective status of skin, appendages, and several mucosal sites. Method. Postmenopausal women ( 𝑛 = 1 0 9 ) were randomly assigned to receive either two daily capsules of the active compound (80 mg RCE, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Subjective improvement of skin, appendages, and several mucosal site status was assessed for each studied group at 90 and 187 days using a visual analogue scale (VAS). In addition, libido, tiredness, and urinary, sleep, and mood complaints were also evaluated. Results. Women after RCE intervention (both groups) reported better subjective improvement of scalp hair and skin status, libido, mood, sleep, and tiredness. Improvement of urinary complaints, nail, body hair, and mucosa (oral, nasal, and ocular) status did not differ between treatment phases (intra- and intergroup). Overall satisfaction with treatment was reported higher after RCE intervention (both groups) as compared to placebo. Conclusion. RCE supplementation exerted a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.