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Obstetrics and Gynecology International
Volume 2012 (2012), Article ID 134962, 8 pages
http://dx.doi.org/10.1155/2012/134962
Clinical Study

Expression and Prognostic Significance of Wnt7a in Human Endometrial Carcinoma

1Department of Obstetrics and Gynecology, Harbin Red Cross Hospital, Harbin 150076, China
2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, no. 23 Youzheng Street, Nangang Block, Harbin 150010, China
3Department of Obstetrics and Gynecology, The Fifth Hospital of Daqing, Heilongjiang, China

Received 20 July 2012; Accepted 22 October 2012

Academic Editor: Robert Coleman

Copyright © 2012 Chunjie Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation as well as tumorigenesis and progression. However, less is understood about the role of Wnt7a in human endometrial carcinoma. The aim of this study is to investigate the expression and prognostic significance of Wnt7a in endometrial carcinoma. Methods. Wnt7a expression was immunohistochemically examined in 35 normal endometrium, 33 hyperplastic endometrium and 70 endometrial carcinomas. Results. Wnt7a expression was lower in endometrial carcinomas compared with that in normal and hyperplastic endometrium ( ). Wnt7a was inversely correlated with FIGO stage ( ), grade ( ), lymph node metastasis ( ), depth of myometrial invasion ( ), lymph vascular space involvement ( ) and peritoneal cytology ( ). There was a negative correlation between estrogen receptor (ER) and Wnt7a ( , ), and a positive correlation between progestogen receptor (PR) and Wnt7a ( , ). Patients with lost or reduced Wnt7a expression had poorer progression-free survival (PFS) and overall survival (OS) ( and , resp.) on univariate analysis. But on multivariate analysis, Wnt7a expression was not an independent prognostic factor for PFS or OS. Conclusions. Our results indicate that Wnt7a expression may serve as an important prognostic marker.