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Obstetrics and Gynecology International
Volume 2012 (2012), Article ID 147867, 7 pages
http://dx.doi.org/10.1155/2012/147867
Clinical Study

Safety and Efficacy of an Intravaginal Prebiotic Gel in the Prevention of Recurrent Bacterial Vaginosis: A Randomized Double-Blind Study

1Alliospharma, 1 Allée des Ecureuils, 69380 Lissieu, France
2Department of Obstetrics, Gynecology & Reproduction, Maternité Régionale Universitaire, 10 rue du Dr Heydenreich, 54042 Nancy, France
3Novescia, 29 rue de la bienfaisance, 75008 Paris, France

Received 16 October 2012; Accepted 26 November 2012

Academic Editor: Everett Magann

Copyright © 2012 Isabelle Coste et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. This study was performed to evaluate the efficacy and safety of a prebiotic treatment in the balance recovery of the vaginal flora in subjects previously treated for bacterial vaginosis (BV). Study Design. A randomized trial was carried out on 42 subjects with an active prebiotic group compared to a placebo group. The main evaluation criterion was the quantification of the vaginal flora measured by the Nugent score. Secondary criteria included vaginal pH and BV recurrence. Results. After 8 days of treatment, all subjects who received the prebiotic had a normal Nugent score, whereas 33% of the subjects treated with placebo had an intermediate or positive Nugent score. After 16 days of application, a normal Nugent score was maintained in all subjects treated with the prebiotic, whereas in the placebo group 24% of the subjects still had an elevated Nugent score. Moreover, the maintenance of (or reversion to) a normal flora was associated with the maintenance of (or reversion to) physiological pH values. Conclusions. The intravaginal gel treatment improves the recovery of a normal vaginal flora after the treatment of a BV episode, which should warrant a reduction in the risk of further recurrences.