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Obstetrics and Gynecology International
Volume 2012 (2012), Article ID 238061, 8 pages
doi:10.1155/2012/238061
Review Article
Fertility-Sparing Surgery in Early Epithelial Ovarian Cancer: A Viable Option?
Department of Gynecology, European Competence Center for Ovarian Cancer, Campus Virchow Clinic, Charité University Hospital, 13353 Berlin, Germany
Received 2 November 2011; Accepted 19 December 2011
Academic Editor: Howard D. Homesley
Copyright © 2012 Christina Fotopoulou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- S. Vaughan, J. I. Coward, R. C. Bast Jr. et al., “Rethinking ovarian cancer: recommendations for improving outcomes,” Nature Reviews Cancer, vol. 11, no. 10, pp. 719–725, 2011. View at Publisher · View at Google Scholar · View at PubMed
- C. Fotopoulou, K. Savvatis, G. Schumacher, W. Lichtenegger, and J. Sehouli, “Surgical outcome and survival analysis of young patients with primary epithelial ovarian cancer,” Anticancer Research, vol. 29, no. 7, pp. 2809–2815, 2009.
- A. C. Schlaerth, D. S. Chi, E. A. Poynor, R. R. Barakat, and C. L. Brown, “Long-term survival after fertility-sparing surgery for epithelial ovarian cancer,” International Journal of Gynecological Cancer, vol. 19, no. 7, pp. 1199–1204, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. E. Bristow, B. E. Palis, D. S. Chi, and W. A. Cliby, “The National Cancer database report on advanced-stage epithelial ovarian cancer: impact of hospital surgical case volume on overall survival and surgical treatment paradigm,” Gynecologic Oncology, vol. 118, no. 3, pp. 262–267, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Fotopoulou, G. Schumacher, J. C. Schefold, C. Denkert, W. Lichtenegger, and J. Sehouli, “Systematic evaluation of the intraoperative tumor pattern in patients with borderline tumor of the ovary,” International Journal of Gynecological Cancer, vol. 19, no. 9, pp. 1550–1555, 2009. View at Scopus
- N. Rasool and P. G. Rose, “Fertility-preserving surgical procedures for patients with gynecologic malignancies,” Clinical Obstetrics and Gynecology, vol. 53, no. 4, pp. 804–814, 2010. View at Publisher · View at Google Scholar · View at PubMed
- G. Mangili, C. Sigismondi, D. Lorusso et al., “Is surgical restaging indicated in apparent stage IA pure ovarian dysgerminoma? The MITO group retrospective experience,” Gynecologic Oncology, vol. 121, no. 2, pp. 280–284, 2011.
- E. S. Abdel-Hady, H. R. Abdel-Hady, A. Gamal, and M. El-Shamey, “Fertility sparing surgery for ovarian tumors in children and young adults,” Archives of Gynecology and Obstetrics, vol. 285, no. 2, pp. 469–471, 2012.
- S. Palomba, A. Falbo, S. del Negro et al., “Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up,” Human Reproduction, vol. 25, no. 8, pp. 1966–1972, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Y. Park, D. Y. Kim, D. S. Suh et al., “Outcomes of fertility-sparing surgery for invasive epithelial ovarian cancer: oncologic safety and reproductive outcomes,” Gynecologic Oncology, vol. 110, no. 3, pp. 345–353, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. M. Schilder, A. M. Thompson, P. D. DePriest et al., “Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility-sparing therapy,” Gynecologic Oncology, vol. 87, no. 1, pp. 1–7, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. Zanetta, S. Chiari, S. Rota et al., “Conservative surgery for stage I ovarian carcinoma in women of childbearing age,” British Journal of Obstetrics and Gynaecology, vol. 104, no. 9, pp. 1030–1035, 1997. View at Scopus
- H. Kajiyama, K. Shibata, M. Mizuno et al., “Fertility-sparing surgery in young women with mucinous adenocarcinoma of the ovary,” Gynecologic Oncology, vol. 122, no. 2, pp. 334–338, 2011. View at Publisher · View at Google Scholar · View at PubMed
- American College of Obstetricians and Gynecologists, “ACOG Practice Bulletin: management of adnexal masses,” Obstetrics & Gynecology, vol. 110, pp. 201–214, 2007.
- S. Aebi and M. Castiglione, “Epithelial ovarian carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 19, no. 2, supplement 2, pp. ii14–ii16, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- T. Satoh, M. Hatae, Y. Watanabe et al., “Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection,” Journal of Clinical Oncology, vol. 28, no. 10, pp. 1727–1732, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- I. M. Shih and R. J. Kurman, “Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis,” American Journal of Pathology, vol. 164, no. 5, pp. 1511–1518, 2004. View at Scopus
- Y. S. Kwon, H. S. Hahn, T. J. Kim et al., “Fertility preservation in patients with early epithelial ovarian cancer,” Journal of Gynecologic Oncology, vol. 20, no. 1, pp. 44–47, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Kajiyama, K. Shibata, S. Suzuki et al., “Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?” Gynecologic Oncology, vol. 111, no. 3, pp. 523–526, 2008. View at Publisher · View at Google Scholar · View at PubMed
- C. Borgfeldt, C. Iosif, and A. Måsbäck, “Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 134, no. 1, pp. 110–114, 2007. View at Publisher · View at Google Scholar · View at PubMed
- H. Kajiyama, K. Shibata, M. Mizuno et al., “Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery,” British Journal of Cancer, vol. 105, no. 9, pp. 1288–1294, 2011. View at Publisher · View at Google Scholar · View at PubMed
- H. Kajiyama, K. Shibata, M. Mizuno et al., “Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: is it possible?” Human Reproduction, vol. 26, no. 12, pp. 3297–3302, 3302. View at Publisher · View at Google Scholar · View at PubMed
- H. Kajiyama, K. Shibata, S. Suzuki et al., “Fertility-sparing surgery in young women with invasive epithelial ovarian cancer,” European Journal of Surgical Oncology, vol. 36, no. 4, pp. 404–408, 2010. View at Publisher · View at Google Scholar · View at PubMed
- E.-I. Braicu, J. Sehouli, R. Richter, K. Pietzner, C. Denkert, and C. Fotopoulou, “Role of histological type on surgical outcome and survival following radical primary tumour debulking of epithelial ovarian, fallopian tube and peritoneal cancers,” British Journal of Cancer, vol. 105, no. 12, pp. 1818–1824, 2011.
- A. Bamias, T. Psaltopoulou, M. Sotiropoulou et al., “Mucinous but not clear cell histology is associated with inferior survival in patients with advanced stage ovarian carcinoma treated with platinum-paclitaxel chemotherapy,” Cancer, vol. 116, no. 6, pp. 1462–1468, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. H. Partridge, K. J. Ruddy, S. Gelber et al., “Ovarian reserve in women who remain premenopausal after chemotherapy for early stage breast cancer,” Fertility and Sterility, vol. 94, no. 2, pp. 638–644, 2010. View at Publisher · View at Google Scholar · View at PubMed
- K. Lutchman Singh, S. Muttukrishna, R. C. Stein et al., “Predictors of ovarian reserve in young women with breast cancer,” British Journal of Cancer, vol. 96, no. 12, pp. 1808–1816, 2007. View at Publisher · View at Google Scholar · View at PubMed
- K. Hancke, V. Isachenko, E. Isachenko, and J. M. Weiss, “Prevention of ovarian damage and infertility in young female cancer patients awaiting chemotherapy-clinical approach and unsolved issues,” Supportive Care in Cancer, vol. 19, no. 12, pp. 1909–1919, 2011. View at Publisher · View at Google Scholar · View at PubMed
- P. Morice, E. Leblanc, A. Rey et al., “Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Française d'Oncologie Gynécologique),” Human Reproduction, vol. 20, no. 5, pp. 1379–1385, 2005. View at Publisher · View at Google Scholar · View at PubMed
- P. Morice, F. Wicart-Poque, A. Rey et al., “Results of conservative treatment in epithelial ovarian carcinoma,” Cancer, vol. 92, no. 9, pp. 2412–2418, 2001. View at Publisher · View at Google Scholar
- F. Raspagliesi, R. Fontanelli, D. Paladini, and E. M. di Re, “Conservative surgery in high-risk epithelial ovarian carcinoma,” Journal of the American College of Surgeons, vol. 185, no. 5, pp. 457–460, 1997. View at Publisher · View at Google Scholar
- B. B. O. Ustaalioglu, A. Bilici, U. Kefeli et al., “A retrospective analysis of women's chances to become pregnant after completion of chemotherapy: a single center experience,” Journal of B.U.ON., vol. 16, no. 2, pp. 349–352, 2011.
- S. S. Kim, J. R. Lee, B. C. Jee et al., “Use of hormonal protection for chemotherapy-induced gonadotoxicity,” Clinical Obstetrics and Gynecology, vol. 53, no. 4, pp. 740–752, 2010. View at Publisher · View at Google Scholar · View at PubMed
- K. Behringer, L. Wildt, H. Mueller et al., “No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group,” Annals of Oncology, vol. 21, no. 10, pp. 2052–2060, 2010. View at Publisher · View at Google Scholar · View at PubMed
- S. J. Tan, Y. C. Yeh, W. J. Shang, G. J. Wu, J. Y. Liu, and C. H. Chen, “Protective effect of a gonadotropin-releasing hormone analogue on chemotherapeutic agent-induced ovarian gonadotoxicity: a mouse model,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 149, no. 2, pp. 182–185, 2010. View at Publisher · View at Google Scholar · View at PubMed
- Z. Blumenfeld and M. von Wolff, “GnRH-analogues and oral contraceptives for fertility preservation in women during chemotherapy,” Human Reproduction Update, vol. 14, no. 6, pp. 543–552, 2008. View at Publisher · View at Google Scholar · View at PubMed
- F. E. Duncan, J. K. Jozefik, A. M. Kim, J. Hirshfeld-Cytron, and T. K. Woodruff, “The gynecologist has a unique role in providing oncofertility care to young cancer patients,” US Obstetrics and Gynecology, vol. 6, no. 1, pp. 24–34, 2011.
- L. Lotz, M. Montag, H. van der Ven et al., “Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice - No evidence of malignant cell contamination,” Fertility and Sterility, vol. 95, no. 8, pp. 2612–2614.e1, 2011. View at Publisher · View at Google Scholar · View at PubMed
- R. Soleimani, E. Heytens, R. van den Broecke et al., “Xenotransplantation of cryopreserved human ovarian tissue into murine back muscle,” Human Reproduction, vol. 25, no. 6, pp. 1458–1470, 2010. View at Publisher · View at Google Scholar · View at PubMed