Table 1: Relevant case series reports in the literature concerning fertility-sparing surgery in epithelial ovarian cancer: oncologic outcome.

Author [reference]Pts
Median Age (y)FIGO stage
(%)
Grade
(%)
Histology
(%)
Relapse rate
(%)
Mean PFS (mo) or 5 y DFSCharacteristics of pts who relapsed5 y OSDeathLND

Kwon et al. 2009 [18]2126.717 (81%) IA
4 (19%) IC
16 (76%) G1
3 (14%) G2
2 (9.5%) G3
16 (76%) muc
2 (9.5%) endom
2 (9.5%) clear cell
1 (4.7%) serous
1 (4.7%)34IC, mucNRNRYes
Kajiyama et al. 2008 [19]1035.94 (40%) IA
6 (60%) IC
NR10 (100%) clear cell1 (10%)33IC, G2,
clear cell
NR1 (10%)Optional
Schlaerth et al. 2009 [3]20 2711 (55%) IA
9 (45%) IC
14 (70%) G1
5 (25%) G2
1 (5%) G3
11 (55%) muc
1 (5%) serous
6 (30%) endom
1 (5%) clear cell
3 (15%)4.3
(9–22)
2 IC,
1 IA
84%3 (15%)Yes
Borgfeldt et al. 2007 [20]11NOIA
IC
G1
G3
NR1 (9%)NRIC, G3NRNRYes
Schilder et al. 2002 [11]522642 (81%) IA
10 (19%) IC
38 (73%) G1
9 (17%) G2
5 (9.6%) G3
25 (48%) muc
10 (19%) serous
5 (9.6%) clear cell
2 (4%) mixed
5 (9.6%)14
(8–78)
4 IA, G1
1 IC, G2
2 muc
2 serous
1 endom
98%2 (4%)Yes
Kajiyama et al. 2011 [21]74<4036 (48%) Ia
1 (1.3%) Ib
37 (50%) Ic
57 (77%)
G1/G2
4 (5.4%) G3
4 (5.4%) serous
43 (58%) muc
13 (18%) clear cell
4 (5.4%) endom
NR87.9%
5 y DFS
NR90.8%2 (2.7%)Yes
Zanetta et al. 1997 [12]562932 (57%) : IA
2 (3.5%) : IB
22 (39%) : IC
35 (62%) G1
14 (25%) G2
7 (12%) G3
18 (32%) serous
23 (41%) muc
13 (23%) endom
5 (9%)NR2 IA,G2, endom
1 IA, G3, muc
1 IA, G1, serous
1 IC, G2, serous
NR4 (7%)Yes
Satoh et al. 2010 [16]21129126 (60%) IA
85 (40%) IC
G1: 160 (76%)
G2: 15 (7%)
G3 6 (2.8%)
clear cell: 30 (14.2%)
126 (60%) muc
27 (13%) serous
27 (13%) endom
30 (14.2%) Clear cell
18 (8.5%)33.3–100% 5 y DFSMostly
Ic,G3
Ia, G3
Ic, clear cell
66.7–100%5 (2.4%)Yes
Kajiyama et al. 2011 [13]41<40 y27 (66%) : IA
14 (34%) : IC
NR100% muc
3 (7.3%)90.5%97.3%1 (2.5%)Yes
Kajiyama et al. 2011 [22]803540 (50%) IA
40 (50%) IC
45 (56%) muc
3 (3.75%)serous
15 (19%) endom
16 (20%) clear cell
10 (12.5%)85.5%–92.9% 5 y DFS2: IA
8: IC
89.3%– 90.5%0Yes
Kajiyama et al. 2010 [23]6030IA 30 (50%)
IB 1 (1.7%)
IC 29 (48%)
41 (68%) G1
7 (12%) G2
2 (3.3%) G3
Serous 5 (8.3%)
Muc. 34 (56.7%)
Endom 11 (18 %)
Clear cell 10 (17%)
8 (13%)89.8%2 IA, 1 IB
5 IC
89.8%0

Total58026–35.9333 (57%) IA
4 (0.7%) IB
234 (40%) IC
334 (57%) G1
39 (6.7%) G2
20 (3.4%) G3
300 (52%) muc
51 (9%) serous
128 (22%) clear cell
65 (11%) endom
50 (8.6%)33.3–100%
5 y DFS
66.7–100%18 (3.1%)Yes

muc: mucinous; endom: endometrioid.