|
| Drug (trade name) | Intended use | Mechanism | Potential side effects |
|
| Domperidone (Motilium) | Antiemetic treatment of reflux disease | Peripheral dopamine antagonist | (i) Maternal cardiac arrhythmia
(ii) Possible neurological side effects in infants
(iii) Dry mouth, abdominal cramps, and headache
(iv) Not approved in the United States |
|
| Metoclopramide (Maxeran) | Antiemetic | Dopamine antagonist | Drowsiness, restlessness, fatigue, anxiety, insomnia, depression, sedation, and pseudo-Parkinsonism
Pediatric: prolonged clearance in infants which can result in high serum levels and a risk for methemoglobinemia. Side effects are more common in children |
|
| Sulpiride (Eglonyl) | Schizophrenia Antipsychotic Antidepressant | Selective dopamine antagonist | Extrapyramidal reactions and sedation in adults as well as suspected potential neonatal endocrinological effects
Excreted in breastmilk |
|
| Chlorpromazine (Thorazine) | Antipsychotic | Increases prolactin | Sedation, lethargy, and risk of apnea
Pediatric: SIDS |
|
| HGH human growth hormone (Somatotropin) | Hormone purified polypeptide of recombinant DNA | Stimulates milk production | Hypoglycemia
Pediatric: absorption from breastmilk is unlikely |
|
| THR thyrotrophin releasing hormone | Treatment of hypothyroidism | Affects prolactin release | Theoretically may cause hyperthyroid condition in infants |
|
| Oxytocin (Pitocin Syntocinon) | Endogenous nonapeptide hormone | Stimulates milk ejection reflex | Hypotension, hypertension, water intoxication and excessive uterine contractions, bradycardia, and arrhythmias
Pediatric: neonatal jaundice |
|
