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Obstetrics and Gynecology International
Volume 2012 (2012), Article ID 578490, 8 pages
http://dx.doi.org/10.1155/2012/578490
Review Article

Controversies in the Treatment of Early Stage Endometrial Carcinoma

Division of Gynaecologic Oncology, Segal Cancer Center, Jewish General Hospital, McGill University, Montreal, QC, Canada H3T 1E2

Received 20 September 2011; Accepted 18 January 2012

Academic Editor: Curt W. Burger

Copyright © 2012 Joshua Z. Press and Walter H. Gotlieb. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite the publication of numerous studies, including some multicentered randomized controlled trials, there continues to be vigorous debate regarding the optimal management of early stage endometrial cancer, including the extent of surgery and the role of adjuvant chemotherapy and radiation. Resolving these questions has become increasingly important in view of the increase of endometrial cancer, related to the aging population and the alarming incidence of obesity. Furthermore, there are more surgical challenges encountered when operating on elderly patients or on patients with increased BMI and the associated comorbidities, such as diabetes, hypertension, heart disease, and pulmonary dysfunction. This paper will focus on the advantages of minimally invasive surgery, the value of lymphadenectomy including sentinel lymph node mapping, and some of the current controversies surrounding adjuvant chemotherapy and radiation.