Review Article
Controversies in the Treatment of Early Stage Endometrial Carcinoma
Table 3
Some important randomized trials comparing external beam radiation therapy to observation or vaginal brachytherapy alone.
| | Treatment comparison | Local recurrence rate | 5-year OS | Distant recurrence rate | G3/4 toxicity |
| | PORTEC-1 | EBRT versus observation | 4% versus 14% () | 81% versus 85% () | 8% versus 7% | 2% versus 0.002% | | GOG99 | EBRT versus observation | 3% versus 12% () | 92% versus 86% () | 5% versus 6% | 5% versus 0.5% | | PORTEC-2 | EBRT versus vaginal brachytherapy alone | 2.1% versus 5.1% () | 80% versus 85% () | 6% versus 8% | 2% versus <1% |
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EBRT—external beam radiation therapy, OS = overall survival.
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