Table 4: Some important studies of chemotherapy in endometrial cancer.

PFS OS Toxicity issues

RCT : GOG 122 (advanced stage) WAR versus chemotherapy (AP) 38% versus 50% 42% versus 55% Treatment-related death 2% versus 4%
RCT : GOG 177 (Advanced stage) Chemotherapy : AP versus TAP 5.3 versus 8.3 12.3 versus 15.3 Grade 3
(months)(months)neuropathy
( ) ( )1% versus 12%
Phase II : RTOG 9708 (All stages) Chemoradiation : pelvic radiation (with concurrent cisplatin) + 4 cycles of TP All stages: 81%
Stage III = 72%
All stages: 85%
Stage III = 77%
Grade 3 = 16%
Grade 4 = 5%

RCT = randomized controlled trial, WAI = whole-abdominal radiation, AP = doxorubicin and cisplatin, TAP = paclitaxel, doxorubicin, cisplatin (+filgrastim), TP = paclitaxel and cisplatin, PFS = progression-free survival, and OS = overall survival.