Multiple Approaches for Individualized Fertility Protective Therapy in Cancer Patients

Table 2

Rate of chemotherapy-induced amenorrhea, according to regimen and age.

Regimen	Age <30 yrs	Age 30–40 yrs	Age >40 yrs
No treatment	1%	< 5%	20–25%
Ac x4	—	13%	60%
CMF x6	19%	35%	85%
CAF/CEF x6	30%	—	85%
AC x4->Dtax	—	55%	—

AC: doxorubicin/cyclophosphamide,
CMF: cyclophosphamide/methotrexate/5-fluorouracil,
CAF: cyclophosphamide/doxorubicin/5-fluorouracil,
CEF: cyclophosphamide/epirubicin/5-fluorouracil,
Dtax: docetaxel.