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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 195454, 6 pages
http://dx.doi.org/10.1155/2013/195454
Clinical Study

Morinda citrifolia (Noni) as an Anti-Inflammatory Treatment in Women with Primary Dysmenorrhoea: A Randomised Double-Blind Placebo-Controlled Trial

1Department of Obstetrics and Gynaecology, The University of the West Indies, Mona, Kingston 7, Jamaica
2Department of Pathology, The University of the West Indies, Mona, Kingston 7, Jamaica
3Tropical Metabolism Research Unit, The University of the West Indies, Mona, Kingston 7, Jamaica
4Faculty of Medical Sciences, The University of the West Indies, Deans Office, Mona, Kingston 7, Jamaica

Received 28 August 2012; Accepted 23 December 2012

Academic Editor: Robert Coleman

Copyright © 2013 H. M. Fletcher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Noni (Morinda citrifolia) has been used for many years as an anti-inflammatory agent. We tested the efficacy of Noni in women with dysmenorrhea. Method. We did a prospective randomized double-blind placebo-controlled trial in 100 university students of 18 years and older over three menstrual cycles. Patients were invited to participate and randomly assigned to receive 400 mg Noni capsules or placebo. They were assessed for baseline demographic variables such as age, parity, and BMI. They were also assessed before and after treatment, for pain, menstrual blood loss, and laboratory variables: ESR, hemoglobin, and packed cell volume. Results. Of the 1027 women screened, 100 eligible women were randomized. Of the women completing the study, 42 women were randomized to Noni and 38 to placebo. There were no significant differences in any of the variables at randomization. There were also no significant differences in mean bleeding score or pain score at randomization. Both bleeding and pain scores gradually improved in both groups as the women were observed over three menstrual cycles; however, the improvement was not significantly different in the Noni group when compared to the controls. Conclusion. Noni did not show a reduction in menstrual pain or bleeding when compared to placebo.