The Natural History of Uterine Leiomyomas: Morphometric Concordance with Concepts of Interstitial Ischemia and Inanosis
Table 1
Summary of individual tumor data.
Fibroid
Size (cm)
Collagenb (%)
Mitoses
PCNA (%)
Factor 8 (microvessel density)
Phasea 1
1a
<2
1.14
1
24.3
92
2a
>2
0.17
0
54.7
79.2
3a
<2
1.86
1
69.9
113.0
4a
>2
0.61
0
35.2
56.6
5a
<2
0.37
0
59.1
119
Average
2 > 2 cm
0.83%
0.4
48.6
92
Phase 2
1b
5.11
0
18.1
45.0
2b
>2
6.04
0
13.4
99.6
3b
>2
11.89
0
56.9
40.2
4b
3.33
1
25.3
25.4
5b
14.64
1
48.8
73.6
Average
3 > 2 cm
8.20%
0.4
32.5
57
Phase 3
1c
>2
30.81
0
3.1
27.0
2c
36.55
0
8.2
8.8
3c
>2
33.36
0
19.1
27.6
4c
29.99
2
50.2
66.8
5c
38.41
0
47.6
56.4
Average
5 > 2 cm
33.82%
0.4
25.6
40
Phase 4
1d
50.02
0
13.8
29.0
2d
72.65
0
19.1
43.6
3d
≥2.0
51.76
0
20.3
18.8
4d
67.42
0
6.3
40.8
5d
58.11
0
15.5
31.6
Average
5 > 2 cm
59.99%
0.0
15.0
33
Phase was based upon light microscopic estimation of the percentage of collagen in the tumor in H&E-stained slides. Collagen (%) was determined by image analysis of Masson’s trichrome-stained slides.
