About this Journal Submit a Manuscript Table of Contents
Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 328909, 5 pages
http://dx.doi.org/10.1155/2013/328909
Research Article

HPV 16 Is Related to the Progression of Cervical Intraepithelial Neoplasia Grade 2: A Case Series

1School of Medical Sciences, State University of Campinas (UNICAMP), 101 Rua Alexander Fleming, 13083-881 Campinas, SP, Brazil
2School of Pharmaceutical Sciences, University of São Paulo (USP), Rua Prof. Lineu Prestes, 580, 05508-000 São Paulo, SP, Brazil
3School of Medicine, Santa Casa de São Paulo, INCT-HPV, Rua Marquês de Itú, 381, 01223-001 São Paulo, SP, Brazil
4School of Pharmacy, Federal University of Goiás, Avenida Universitária, 74605-220 Goiânia, GO, Brazil

Received 24 June 2013; Accepted 24 October 2013

Academic Editor: W. T. Creasman

Copyright © 2013 Maria Gabriela Loffredo D’Ottaviano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. J. F. Snijders, R. D. M. Steenbergen, D. A. M. Heideman, and C. J. L. M. Meijer, “HPV-mediated cervical carcinogenesis: concepts and clinical implications,” Journal of Pathology, vol. 208, no. 2, pp. 152–164, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. R. L. Winer, N. B. Kiviat, J. P. Hughes et al., “Development and duration of human papillomavirus lesions, after initial infection,” Journal of Infectious Diseases, vol. 191, no. 5, pp. 731–738, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. T. Cox, M. Schiffman, and D. Solomon, “Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy,” American Journal of Obstetrics and Gynecology, vol. 188, no. 6, pp. 1406–1412, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Elit, M. N. Levine, J. A. Julian et al., “Expectant management versus immediate treatment for low-grade cervical intraepithelial neoplasia,” Cancer, vol. 117, no. 7, pp. 1438–1445, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. M. G. Discacciati, C. A. S. de Souza, M. G. D'Otavianno et al., “Outcome of expectant management of cervical intraepithelial neoplasia grade 2 in women followed for 12 months,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 155, no. 2, pp. 204–208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. B. Moscicki, S. Shiboski, N. K. Hills et al., “Regression of low-grade squamous intra-epithelial lesions in young women,” The Lancet, vol. 364, no. 9446, pp. 1678–1683, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. A. B. Moscicki, Y. Ma, C. Wibbelsman et al., “Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women,” Obstetrics and Gynecology, vol. 116, no. 6, pp. 1373–1380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Doorbar, “Molecular biology of human papillomavirus infection and cervical cancer,” Clinical Science, vol. 110, no. 5, pp. 525–541, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. L. S. Massad, M. H. Einstein, W. K. Huh et al., “2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors,” Journal of Lower Genital Tract Disease, vol. 17, supplement 5, pp. S1–S27, 2013. View at Publisher · View at Google Scholar
  10. R. M. Scully, T. A. Bonfiglio, R. I. Kurman, S. G. Silverberg, and E. J. Wilkins, Histological Typing of Female Genital Tract Tumors, World Health Organization-International Histological Classification of Tumors, Spring, Berlin, Germany, 2nd edition, 1994.
  11. K. S. Cuschieri, H. A. Cubie, M. W. Whitley et al., “Multiple high risk HPV infections are common in cervical neoplasia and young women in a cervical screening population,” Journal of Clinical Pathology, vol. 57, no. 1, pp. 68–72, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. P. E. Castle, M. H. Stoler, D. Solomon, and M. Schiffman, “The relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an alts report,” American Journal of Clinical Pathology, vol. 127, no. 5, pp. 805–815, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. P. E. Castle, M. Schiffman, C. M. Wheeler, and D. Solomon, “Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2,” Obstetrics and Gynecology, vol. 113, no. 1, pp. 18–25, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Wentzensen, J. Walker, M. Schiffman et al., “Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management,” International Journal of Cancer, vol. 132, no. 1, pp. 148–154, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Schiffman, P. E. Castle, J. Jeronimo, A. C. Rodriguez, and S. Wacholder, “Human papillomavirus and cervical cancer,” The Lancet, vol. 370, no. 9590, pp. 890–907, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. K. Kjær, K. Frederiksen, C. Munk, and T. Iftner, “Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence,” Journal of the National Cancer Institute, vol. 102, no. 19, pp. 1478–1488, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Doobar, “The papillomavirus life cycle,” Journal of Clinical Virology, vol. 325, supplement 1, pp. 7–15, 2005.
  18. R. P. Insinga, E. J. Dasbach, and E. H. Elbasha, “Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: a critical and systematic review of the literature in the development of an HPV dynamic transmission model,” BMC Infectious Diseases, vol. 9, p. 119, 2009. View at Publisher · View at Google Scholar · View at Scopus