Table 4: The results of group and subgroup analyses according to the comparison of mean WHAQ scores changes between groups.

Between groups
ANCOVA model
Premenstrual Menstrual Postmenstrual
Mean WHAQ scoresDSGDRSPSigDSGDRSPSigDSGDRSPSig

Baseline19.49 ± 6.7621.33 ± 8.53 0.25917.13 ± 5.8817.42 ± 6.410.8245.84 ± 1.986.16 ± 2.880.552
Total3rd cycle19.07 ± 6.2714.78 ± 6.280.00017.82 ± 6.1112.98 ± 4.270.0005.96 ± 2.044.80 ± 1.500.000
6th cycle16.24 ± 6.487.62 ± 2.460.00015.40 ± 5.427.49 ± 2.870.0005.38 ± 1.544.29 ± 0.820.000
Baseline7.76 ± 3.217.38 ± 3.770.6107.16 ± 3.025.93 ± 3.200.0661.51 ± 1.361.38 ± 1.480.657
Negative effect3rd cycle7.33 ± 2.955.07 ± 3.130.0007.11 ± 2.994.36 ± 2.680.0001.47 ± 1.380.80 ± 1.140.006
6th cycle5.60 ± 3.101.56 ± 1.520.0005.67 ± 2.991.58 ± 1.340.0001.13 ± 1.270.07 ± 0.330.000
Baseline4.71 ± 3.085.51 ± 3.610.2612.87 ± 2.743.62 ± 2.900.2080.36 ± 0.800.69 ± 1.180.121
Water retention3rd cycle4.51 ± 2.983.64 ± 2.390.0003.51 ± 2.672.42 ± 1.830.0000.56 ± 0.940.29 ± 0.660.005
6th cycle3.87 ± 2.371.98 ± 1.820.0003.22 ± 2.321.33 ± 1.430.0000.38 ± 0.610.16 ± 0.560.043
Baseline4.49 ± 3.295.84 ± 4.310.0974.56 ± 3.175.27 ± 3.600.3220.73 ± 0.960.87 ± 1.120.546
Impaired concentration3rd cycle4.11 ± 3.413.27 ± 3.110.0003.96 ± 2.903.02 ± 2.340.0000.62 ± 0.940.36 ± 0.680.063
6th cycle3.27 ± 3.140.93 ± 1.100.0003.20 ± 2.701.11 ± 1.490.0000.38 ± 0.860.04 ± 0.300.013
Baseline1.84 ± 1.632.09 ± 1.470.4571.53 ± 1.341.80 ± 1.290.3390.18 ± 0.540.27 ± 0.580.452
Increased appetite3rd cycle1.96 ± 1.361.33 ± 1.070.0001.58 ± 1.201.11 ± 0.960.0000.36 ± 0.570.11 ± 0.320.007
6th cycle2.04 ± 1.281.07 ± 1.030.0001.38 ± 1.150.62 ± 0.860.0000.24 ± 0.480.11 ± 0.380.167
Baseline0.64 ± 0.830.51 ± 0.630.3921.04 ± 0.850.80 ± 0.790.1613.02 ± 0.662.96 ± 0.640.626
Feeling of well being3rd cycle1.11 ± 0.911.47 ± 0.730.0081.62 ± 0.752.07 ± 1.010.0022.91 ± 0.763.24 ± 0.860.042
6th cycle1.42 ± 0.812.09 ± 0.670.0001.89 ± 0.832.78 ± 0.670.0003.20 ± 0.763.91 ± 0.290.000
Baseline0.04 ± 0.300.00 ± 0.000.3200.04 ± 0.300.00 ± 0.000.3200.04 ± 0.300.00 ± 0.000.320
Undesirable hair changes3rd cycle0.04 ± 0.300.00 ± 0.001.0000.04 ± 0.300.00 ± 0.001.0000.04 ± 0.300.00 ± 0.001.000
6th cycle0.04 ± 0.300.00 ± 0.001.0000.04 ± 0.300.00 ± 0.001.0000.04 ± 0.300.00 ± 0.001.000

DSG: desogestrel and DRSP: drospirenone.