Adjunctive Therapies to Cerclage for the Prevention of Preterm Birth: A Systematic Review

Table 3

Studies reporting the use of empiric tocolytic agents as an adjunct to cerclage.

Study	Design	Sample Size	Cervical length cutoff for cerclage (mm)	Cerclage type^‡	Mean gestational age (weeks)	Tocolytic	Duration	Outcome	Tocolytic group; rate of PTB	Reference group; rate of PTB
Visintine et al., 2008 [18]	Retrospective cohort	101	<25	Not specified	19 versus 19	Indomethacin	48 hours	PTB < 35 wga	39%	35%
Berghella et al., 2009 [19]	Retrospective cohort	222	Not specified	Not specified	19 versus 18	Indomethacin	48 hours	PTB < 35 wga; PTB < 32 wga; PTB < 28 wga	47%; 39%; 34%	58%; 49%; 37%

PTB: preterm birth and wga: weeks gestational age.