Research Article
The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation
| Phase | Estimated collagen content | Functional status |
| Phase 1 | No, or insignificant, collagen matrix | Proliferation of myocytes | Phase 2 | <10% collagen | Proliferation of myocytes, and synthesis of collagen | Phase 3 | 10–50% collagen | Proliferation, synthesis of collagen, and early senescence in late Phase 3 | Phase 4 | >50% collagen | Involution |
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