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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 708023, 11 pages
http://dx.doi.org/10.1155/2013/708023
Review Article

The Evidence Regarding Maintenance Tocolysis

1Perinatal Services, Division of Southwest Contemporary Women's Care, Southwest Perinatal Services, 16611 S. 40th Street, Phoenix, AZ 85048, USA
2Department of OB/GYN, University of Mississippi Medical Center, Jackson, MS 39216, USA

Received 28 November 2012; Revised 24 January 2013; Accepted 30 January 2013

Academic Editor: Everett Magann

Copyright © 2013 John P. Elliott and John C. Morrison. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Preterm delivery is a public health issue of major proportion. More than 12% of deliveries in the United States that occur at less than 37 weeks gestation preterm labor (PTL) represents the largest single reason for preterm birth (PTB). Attempts to prevent PTB have been unsuccessful. This paper of maintenance tocolytic therapy will examine the efficacy and safety of the drugs, both oral and subcutaneous, which have been utilized for prolongation of pregnancy following successful arrest of a documented episode of acute preterm labor. The evidence for oral tocolytics as maintenance therapy as well as parenteral medications for such patients is offered. Finally, the effects in the United States of the Food and Drug Administration (FDA) action on such medications are reported.